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Scientific Research

IPM researchers publish scientific and technical articles on a variety of topics from product development and clinical trial results to regulatory policy. Scroll through or use the Filtered Search in the left sidebar to locate articles by keyword, research category, drug, journal name or year published.

Preclinical Research

January 2022 | International Journal of Pharmaceuticals: X

In vitro drug release, mechanical performance and stability testing of a custom silicone elastomer vaginal ring releasing dapivirine and levonorgestrel

Murphy DJ, Bashi YHD, McCoy C, Boyd P, Brown L, Martin F, McMullen N, Kleinbeck K, Dangi B, Spence P, Hansraj B, Devlin B, Malcolm RK. Int J Pharm X. 2022 Dec; 4: 100112. doi.org/10.1016/j.ijpx.2022....

December 2021 | Pharmaceutics

Investigating the Contribution of Drug-Metabolizing Enzymes in Drug-Drug Interactions of Dapivirine and Miconazole

Valicherla GR, Graebing P, Zhang J, Zheng R, Nuttall J, Silvera P, Rohan LC. Pharmaceutics. 2021; 13(12): 2193; https://doi.org/10.3390/pharmaceutics13122193.

October 2021 | Drug Delivery and Translational Research

Refining the in vitro release test method for a dapivirine‚ÄĎreleasing vaginal ring to match in vivo performance

Murphy DJ, Lim D, Armstrong R, McCoy CF, Dallal Bashi YH, Boyd P, Derrick T, Spence P, Devlin B, Malcolm RK. Drug Delivery and Translational Research. Eprint: 2021 Oct 21. https://doi.org/10.1007/...

July 2021 | International Journal of Pharmaceuticals: X

Silicone elastomer formulations for improved performance of a multipurpose vaginal ring releasing dapivirine and levonorgestrel

Bashi YHD, Murphy DJ, McCoy CF, Boyd P, Brown L, Kihara M, Martin F, McMullen N, Kleinbeck K, Dangi B, Spence P, Hansraj B, Devlin B, Malcolm RK. Int J Pharm X. 2021 Jul; 3:100091. doi.org/10.1016/j....

May 2021 | International Journal of Pharmaceutics: X

Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

McCoy CF, Spence P, Bashi YHD, Murphy DJ, Boyd P, Dangi B, Derrick T, Devlin B, Kleinbeck K, Malcolm RK. Int J Pharm X. 2021 May 1;3:100081. eCollection 2021 Dec.

July 2019 | International Journal of Pharmaceutics

Towards a dapivirine and levonorgestrel multipurpose vaginal ring: Investigations into the reaction between levonorgestrel and addition-cure silicone elastomers

Bashi YHD, McCoy CF, Murphy D, Boyd P, Spence P, Kleinbeck K, Devlin B, Malcolm RK. International Journal of Pharmaceutics. 26 Jul 2019: epub ahead of print. doi: 10.1016/j.ijpharm.2019.118574. 

June 2019 | AAPS PharmSciTech

Novel Application of Hot Melt Extrusion for the Manufacturing of Vaginal Films Containing Microbicide Candidate Dapivirine

Regev G, Patel SK, Moncla BJ, Twist J, Devlin B, Rohan LC. AAPS PharmSciTech 20, no. 6 (26 Jun 2019): 239. 

May 2019 | International Journal of Pharmaceutics

Drug stability and product performance characteristics of a dapivirine-releasing vaginal ring under simulated real-world conditions

Murphy DJ, McCoy CF, Boyd P, Derrick T, Spence P, Devlin B, Malcolm K. International Journal of Pharmaceutics. 11 May 2019: epub ahead of print. doi.org/10.1016/j.ijpharm.2019.05.027

April 2019 | Pharmaceutics

Design of Poly(lactic-co-glycolic Acid) (PLGA) Nanoparticles for Vaginal Co-Delivery of Griffithsin and Dapivirine and Their Synergistic Effect for HIV Prophylaxis

Yang H, Li J, Patel SK, Palmer KE, Devlin B, Rohan LC. Pharmaceutics 11, no. 4(16 April 2019): 184

April 2019 | International Journal of Pharmaceutics

Development and pharmacokinetics of a combination vaginal ring for sustained release of dapivirine and the protein microbicide 5P12-RANTES

McBride JW, Malcolm RK, Dias N, Cameron D, Offord RE, Hartley O, Kett VL, Devlin B, Boyd P. International Journal of Pharmaceutics. 15 Apr 2019: epub ahead of print. doi.org/10.1016/j.ijpharm.2019.04...

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