Photo: Geoff Oliver Bugbee
IPM advances microbicide candidates that have shown a¬†good safety profile in a preclinical research program¬†through a series of clinical trials.¬†
Acceptability Studies:¬†IPM places high importance on identifying and addressing the social and behavioral aspects of microbicide research from the early stages¬†of our product development efforts. IPM sometimes uses a consumer market research approach to assess product acceptability. To guide product development, information on cultural¬†and sexual practices, risk reduction behaviors, and partner acceptability is also gathered¬†in a variety of settings in developing countries.
HIV Incidence Studies:¬†HIV incidence studies are designed to assess, through regular HIV testing and counseling, the rate of new infections in a community. These studies help identify settings that are suitable for microbicide efficacy trials.
Clinical Trials:¬†Clinical trials are carried out sequentially to ensure only promising candidates advance through all stages of testing. The first, smaller¬†trials determine the safety profile of the product and are followed by larger efficacy trials, which take three or more years and typically involve thousands of volunteers.