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Glossary

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next-generation microbicide

Microbicide products based on the same antiretroviral (ARV) drugs used successfully to treat HIV and to prevent mother-to-child-transmission (PMTCT) of HIV. The first next-generation microbicide was proven efficacious at preventing HIV infection by the CAPRISA 004 trial.

NGO

nongovernmental organization

NNRTI

non-nucleoside reverse transcriptase inhibitor

non-nucleoside reverse transcriptase inhibitor

A class of ARV-based compounds that prevents HIV infection by stopping replication of HIV’s genetic material. NNRTIs bind to the reverse transcriptase enzyme, a protein that HIV needs to convert its genetic material, RNA, into cDNA. Without the enzyme, HIV replication is impossible, and the virus cannot spread.

noncoitally dependent

An intervention that can be applied or used at regular time intervals (e.g., once daily or once monthly) independent of the last time of sexual intercourse.(Contrast with coitally dependent)

nongovernmental organization

Private, not-for-profit organizations that pursue activities to relieve suffering, promote the interests of the poor, protect the environment, or undertake community development.

nucleotide reverse transcriptase inhibitors

A class of ARV-based compounds that prevents HIV infection by blocking the production of viral cDNA. Once a molecule of the NtRTI is incorporated into a growing cDNA chain, that chain is blocked, preventing the virus from producing functional cDNA to infect the cell.